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Because placental protein 13 is essential for initial placental growth and the modulation of maternal immunoreaction via T-cell and macrophage apoptosis, low quantities of this protein in EXOs may be significant for confirming the diagnosis of PE (Pillay et al., 2017)

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10.1007/s12291-014-0446-0 48 PlatzerM.KieseS.HerfellnerT.Schweiggert-WeiszU.MiesbauerO.EisnerP

In internal metal-detoxification, OAs may chelate with metal in the cytosol, where the ions can be transformed into a non-toxic or less toxic form (Clemens, 2002)

the reason is the short half-life and limited storage capacity of thiamine within the organism [19]