glutathione glutathione peroxidase Reaction mechanism of (GPX) Glutathione peroxidase

10.1073/pnas.47.10.1588 130 NormanlyJ.KleinaL

Similarly, Xiong et al

L.CooperN.MunroP

As the core antagonist of lipid peroxidation, GPX4 converts toxic lipid hydroperoxides (L-OOH) into inert lipid alcohols (L-OH) by consuming the reducing power provided by GSH, effectively blocking the propagation of radical chain reactions ( - ) ( - ( 2.4 The critical role of mitochondria in ferroptosis As a core regulatory hub of ferroptosis, mitochondrial dynamic structural and functional disorders run through the entire process of ferroptosis ( 2.5 The dynamic regulatory network of ferroptosis signaling pathways 2.5.1 Oxidative stress response pathway Nrf2, as the central hub of antioxidant defense, binds to Keap1 and is continuously degraded in a resting state ( - , leading to the interruption of GSH synthesis and the inactivation of GPX4 ( 2.5.2 Energy metabolism pathway In the metabolic regulatory network of ferroptosis, the dynamic balance of the energy metabolism pathway profoundly affects the process of lipid peroxidation

Some other small molecule compounds (Table 2) such as alloimperatorin (Zhang J

InClinical Applications of Biomolecules in Disease Diagnosis: A Comprehensive Guide to Biochemistry and Metabolism