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Multiple release transdermal delivery systems are designed to achieve slow and steady and gradual release, also optionally with low intermittent release when desired, of GHK-Cu in such a manner that the rate of release of GHK-Cu solves the problem associated with elimination to half of its original content every 2 hrs

The skin is exposed every day to factors that increase oxidative stress, including UV rays, pollution, inflammation, environmental stress, and disruption of the skin barrier

In contrast, a distinct pharmacological strategy employs copper ionophores, such as elesclomol

375 HSP27 modulators HSP27 modulation has also shown therapeutic promise

JW: Investigation, Writing review & editing

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