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Patients with phenylketonuria receiving l-carnitine (98 mg/day) combined with selenium (31.5 micrograms/day) for six months showed the restoration of GSH-Px activity, and the improvement of protein and lipid oxidative damage [112]

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As genetic variants are determined at conception they are much less affected by the confounders that can bias conventional observational studies, such as socioeconomic position, so MR studies minimize confounding

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