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Tumors can induce fibroblasts to transform into CAFs through various mechanisms, including cytokine signaling, metabolic reprogramming, direct cellcell contact, and microenvironmental stress

Type 2 diabetes: They are used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes

Fluoxetine is unique among SSRIs in having an active metabolite and a long half-life, resulting in delayed onset of action and prolonged effects even after discontinuation