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Importantly, a phenotype-oriented approach may improve clinical relevance, where MI may be prioritized in insulin-resistant individuals, vitamin D in deficient or inflammatory phenotypes, and melatonin in patients with pronounced oxidative stress or circadian disruption

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Together, these results suggested a potential cooperativity of BRD4 and ASXL1 that co-occupy transcriptionally active promoters

Nitric oxide (NO): an emerging target for the treatment of glaucoma

But I think specifically with me, I wrote about optimization in my book in 2017