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By activating CB 2 R, CBD inhibits pro-inflammatory signaling pathways such as NF-B, thereby reducing the production of IL-1 and TNF- ( 2 R can effectively reduce HSC activation by inhibiting the NOX4 and NF-B signaling pathway, which in turn lowers the expression of -SMA and slows down the fibrotic process (Xie et al., 2024)

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The His-Phe-Arg-Trp tetrapeptide core (positions 69) is preserved intact and has been identified as the pharmacophore responsible for melanocortin receptor activation

Total cholesterol was normalized for protein content and expressed as percentage

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