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Nevertheless, a meta-analysis of 15 randomized controlled trials (RCTs) demonstrated that probiotic supplementation significantly shortened whole-gut transit time, improved stool consistency, and increased stool frequency (392)

PMID 19625176

Eur J Immunol

29, 56, 59, 60 As insulin stimulates the sympathetic nervous system, 71, 72 and as obese patients have increased sympathetic nervous system activity, 73, 74, 75 a role for insulin-mediated sympathetic nervous system stimulation seems a likely factor in the pathogenesis of high blood pressure in the setting of central obesity, as supported by studies demonstrating concomitant decreases in blood pressure and sympathetic nervous system activity when insulin is lowered by low-energy diets in obese patients

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