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Nodules may persist for weeks or even months with the result of their contents hardening into deep cysts

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Moreover, bacterial translocation and systemic DAMPs (e.g., cold-inducible RNA-binding protein (CIRP) activate pulmonary TLR4, driving NF-B and p38 MAPK pathways that intensify inflammation and endothelial damage[34, 77, 78]

doi: 10.1016/j.jsbmb.2015.09.003 143 Luque-RamirezMAlvarez-BlascoFAlpanesMEscobar-MorrealeHF

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Bile is accumulated from hepatocytes into ducts where they eventually move this substance into the gallbladder to be stored until needed for use