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Targeting key metabolic nodes, especially in combination with immune checkpoint inhibitors such as anti-PD-1, holds great promise for achieving novel therapeutic breakthroughs in the management of metastatic CRC

Wang and Gu, 2014), c-Jun/AP-1 (Marshall et al., 2000), NF-B (Pineda-Molina et al., 2001), heat shock factor 1 (HSF1

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www.sciencedirect.com Sarcopenia, the loss of muscle mass and function with age, reduces mobility and quality of life

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This approach allows the physician to clearly identify semaglutide-related side effects before adding another variable