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In fact, an increase in lipid peroxidation biomarkers like 4-hydroxynonenal (4-HNE) have been found in ASD patients frontal lobe (Liu et al., 2022), potentially impairing key cellular mechanisms like membrane transport and mitochondrial respiration (Arakawa & Ito, 2007)

Interestingly, the SOD activity in the red blood cells was elevated in ASD children if compared to the control group and that is probably because this mechanism acts against the cell damage caused by the oxidative stress in the brain (Pangrazzi et al., 2020a)