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78 On the flip side, insulin resistance single-nucleotide polymorphisms and lifestyles combined synergistically increased the risk of breast cancer in a gene-behavior, dose-dependent manner, suggesting lifestyle changes can prevent breast cancer in women who carry the risk genotype

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This intracrine pathway operates independently of PTH and is instead driven by local inflammatory mediators such as interferon- (IFN-) and lipopolysaccharide (LPS) [96, 99]

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