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In neonatal practice, aminoglycosides are most commonly prescribed as empiric combination therapy for suspected sepsis, with the expectation that treatment will be reassessed and narrowed within 4872 h once culture results and clinical response are available ( Management of established ototoxicity Early identification and intervention planning Even when exposure optimization strategies are employed, early identification of ototoxic injury remains essential, as cochlear damage may progress despite appropriate dosing and monitoring

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