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Additional glutamine residues can confer toxicity through various mechanisms, including irregular protein folding and degradation pathways, altered subcellular localization, and aberrant interactions with other cellular proteins [141]

Bokeriya LA, Boldyrev AA, Movsesyan RR, Alikhanov SA, Arzumanyan ES, Nisnevich ED, Artyukhina TV, Serov RA

mBio 5 , (2014)

This regimen would hypothetically be similar to how medical management would be prescribed in humans with small AAAs that do not yet meet the traditional size criteria for operative intervention

Lighting was maintained at 16-17 lx in the open arms, 10-11 lx in the central area and 5-7 lx in the closed arms

145 Under oxidative stress, Cys34 thiol shifts to a sulfenic acid (HSA-SOH), which can be irreversibly oxidized to the sulfinic (HSA-SO2H) and sulfonic (HSA-SO3H) acids or, through the reactions with glutathione, can be returned to the HSA-SH reduced form