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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

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Oral formulations rely on passive absorption but, owing to the pathophysiology of the condition, patients with pernicious anaemia will only absorb around 1% of an orally administered dose[23]