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Furthermore, consistent with the immune-linked neurotoxicity/neuroprotection theory, this meta-analysis revealed elevated levels of quinolinic acid, which is strongly neurotoxic, and decreased levels of kynurenic acid, which is neuroprotective, in MDD patients with melancholic and psychotic features [135]

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Despite these obstacles, GlyT1 pharmacology remains a compelling area of research, holding promise for the development of novel therapeutic strategies targeting neurological and psychiatric disorders with currently limited treatment options (Harsing Jr et al

Li B, Zhou P, Xu K, Chen T, Jiao J, Wei H, Yang X, Xu W, Wan W, Xiao J (2020) Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma