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These changes are not only due to reduced oxygen supply but also related to chronic illness burden and endocrine dysfunction, especially in patients with iron overload from repeated transfusions [3][9]

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Cyanocobalamin is also used to perform the Schilling test to check ability to absorb vitamin B 12

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While many promising approaches (cytogenetic and multiple omics approaches) are currently under investigation to identify dose-dependent biomarkers with the potential to provide rapid field-deployable biodosimetry tests, as of the writing of this review, no FDA-cleared devices are available

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Levels of cellular NAD + were measured using NAD/NADH quantification kits according to the manufacturers instructions (Sigma-Aldrich, MAK037)

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