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Topical TXA efficacy varies, some studies showing efficacy comparable to hydroquinone in treating melasma [7, 75] while other trials have found no significant difference compared to placebo [175]

Wang Y, Goodrich JM, Gillespie B, et al

The animals were allowed to acclimatize for 2 weeks under a 12/12 h dark/light cycle, and under controlled environmental conditions, including a temperature of 22 2 C, relative humidity of 5060%, and adequate ventilation

Regulatory frameworks for these interventions remain underdeveloped, with an urgent need for targeted quality control standards and trial guidelines specific to each modality

However, it is not available in the USA

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