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This supports the hypothesis that meningococcal translocation across brain barriers occurs primarily through the endothelium, without the active participation of immune cells

Sheline YI, Liston C, McEwen BS

The major adverse effects of topical retinoids and topical vitamin C are local skin irritation, including erythema, peeling, dryness, burning and itching, which depend on the concentration and formulation of the product (129,130)