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Abnormalities in mitochondria signaling lead to the production of free radicals like reactive oxygen species (ROS), which causes DNA damage, affecting neural plasticity and behavior [150]

They detect harmful stimuli through Pattern Recognition Receptors (PRRs) by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (98) (Figure 3)

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291 Hypoxia plays a pivotal role in CSC maintenance and therapy resistance by stabilizing hypoxia-inducible factors (HIF-1 and HIF-2), which activate signaling pathways involved in stemness, metabolic reprogramming, EMT, and DNA repair

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The coefficient of determination (R 2 ) was determined for NAC and Di-NAC, R 2 = 1.0 for NAC and R 2 = 1.0 for Di-NAC, respectively