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Based on data coming from studies employing specific CYP isozyme substrates, it appeared that the rate of CYP1A2 and CYP2C19 drug-substrate metabolism decreases with age, whereas the CYP3A4-, CYP2A6-, CYP2C9- and CYP2D6-dependent substrate metabolism is slightly or not modified (102, 130, 131)

Data were normalized based on the recoveiy of the internal standard

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