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[DOI] [PubMed] [Google Scholar] 30.Kapadia G.J., Azuine M.A., Sridhar R., Okuda Y., Tsuruta A., Ichiishi E., Mukainakec T., Takasakid M., Konoshimad T., Nishinoc H., et al

This is also why freckle fading treatment always begins with sun protection, removing the activation trigger is step one in any effective approach

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Measurements such as waist circumference or body fat percentage testing may show modest improvements