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A closed conformational state of IRAP is created that is believed to be induced upon ligand binding

Dror, D

"European Union underinvestment in endometriosis research"

Finally, the authors showed that in an untreated xenograft induced by injecting 50%/50% mixture of p53 positive and negative cells, the less hypoxic areas, closer to the vessels, were richer in p53 + positive cells than the sections of tumours more distant from the blood supply