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Sample sizes were chosen based on our previous experience with similar experiments and on sample sizes reported in previous publications in the field

Additionally, the lncRNA LIPE-AS1 is highly expressed in PCOS follicular fluid EVs and modulates steroid metabolism, granulosa cell proliferation, and apoptosis through the LIPE-AS1/miR-4306/LHCGR axis, contributing to poor oocyte quality and impaired embryo development (Yu et al., 2024)

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Biochimica et Biophysica Acta - Molecular Basis of Disease

Genetic variants including GIPR rs1800437 , GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313 relate to the biological pathways these medications act on