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Based on these conflicted results, the association was speculated to be related to the clinical features of the population, stages of the disease, severity of copper excess, and types of detected specimens in these studies (Table 1)

This is achieved through reduced CBS activity, which leads to downregulation of the trans-sulfuration pathway, and is accompanied by increases of BHMT and MTR, in order to enhance homocysteine remethylation capacity (Fig

Moreover, the hyperhomocysteinemia associated with an increased cardiovascular risk is stronger in non-insulin-dependent diabetes mellitus than in normal subjects (Hoogeveen et al, 1998)

Immunofluorescence analysis showed that Gpx3 was expressed by bronchial epithelial cells and interstitial fibroblasts and localized to the basement membrane and interstitial ECM in lung tissue

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