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Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of parkinsons disease

In agreement, TRPM1 knockout in mice results in a clinical pattern similar to the night blindness pathology (Morgans et al., 2009

The ability to target drugs to specific tissues (e.g., cancer cells) or organs (e.g., brain) is highly desirable both from the standpoint of lowering therapeutic dose as well as reducing side effects

Ketones in traumatic brain injury Ketones have shown promise in traumatic brain injury (TBI), where increased glucose demand and concomitant decreased availability perpetuate secondary neuronal injuries [75]