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One dose of oral hexarelin protects chronic cardiac function after myocardial infarction Mao Y, Tokudome T, et al

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93,94 Tail-anchored membrane proteins with minimal exposure to the ER lumen are recognized by membrane-associated RING C3HC4 finger 6 (MARCHF6) following cleavage of their tail domains by signal peptide peptidase (SPP) 95,96,97 to enable ubiquitination

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A novel cereblon modulator recruits GSPT1 to the CRL4 CRBN ubiquitin ligase

The presence of resistance phenotypes in the vaginal microbiome poses a major threat to human health, with some infections leading to infertility, widespread scarring in the genital tract, miscarriage and preterm birth, and an increased risk of co-infections with human immunodeficiency virus (HIV) 6,7,8