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Behavioral tests were performed to assess whether metformin could alleviate OA-induced pain sensitivity (Fig

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Antihypertensive drugs such as ACE inhibitors act to interfere with conversion of angiotensin I to the biologically active form angiotensin II, and angiotensin receptor blockers (ARBs) act as antagonists at the AT1 receptor thus preventing angiotensin II binding

The analysis revealed that isoquercitrin decreased Keap1 expression, thereby promoting Nrf2 nuclear translocation and upregulating the expression of Nrf2 and its downstream target GCLC