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Smoking can also contribute to high blood pressure, increasing the risk of strokes and worsening kidney disease

Other factors, such as sun exposure, genes, and lifestyle can also contribute to a loss of facial volume and sagging skin

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These agentsranging from traditional cytotoxics to targeted therapiesare increasingly used across cancer types including breast, colorectal, lung, and hematologic malignancies

It is important to emphasize that these findings are derived exclusively from experimental and animal research, and comprehensive clinical studies are required to evaluate safety, effectiveness, and potential relevance in human cardiovascular conditions