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In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence

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All cases were followed up for 7 weeks

For example, glycopeptide hydrogels constructed through dynamic covalent bonds, such as Schiff base bonds and borate ester bonds, and supramolecular interactions such as hydrogen bonds, stacking, and electrostatic interactions, exhibit excellent biocompatibility and degradability while supporting the regulation of mechanical properties, drug release, and immune microenvironment modulation according to specific environmental needs

No RCT with Se as the only intervention agent was published and the three RCT included in the review used different dietary components in addition to Se, making comparisons between studies difficult