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Deferiprone enhances temozolomide cytotoxicity in glioma cells

Elevated levels of ferritin and transferrin, markers of iron dysregulation, have been observed in clinical ARDS cases, linking iron metabolism to disease severity ( Mitochondrial dysfunction exacerbates iron-driven ferroptosis by impairing the organelles ability to sequester and regulate iron levels

SARS-CoV-2 invades cells by binding to ACE2, which leads to downregulation of ACE2 and feedback increased Ang II in the circulation, thus triggering NOX activation, resulting in oxidative stress and inflammation (Hikmet et al., 2020)

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Reduction of TMAO level enhances the stability of carotid atherosclerotic plaque through promoting macrophage M2 polarization and efferocytosis