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- Cancer: Some studies suggest that excessive vitamin B12 intake in patients with existing cancer could have a long-term impact on prognosis

Science 347 , 14361441 (2015)

Chen JJ, Thiyagarajah M, Song J, Chen C, Herrmann N, Gallagher D, et al

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People with higher starting BMI Individuals with BMI above 40 often see faster absolute weight loss in the early phases, simply because a higher body weight means a larger caloric expenditure even at rest, and the same percentage reduction in food intake creates a larger absolute caloric deficit