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Factors upstream of PARP-1, such as JNK1/2 and ERK1/2, may also regulate cell death following PARP-1 inhibition (108)

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390 RegueiroJ.Snchez-GonzlezC.Vallverd-QueraltA.Simal-GndaraJ.Lamuela-RaventsR.Izquierdo-PulidoM

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Nevertheless, clinical trials evaluating the synergistic effect of periodontal therapy under local anesthesia combined with intralesional corticosteroids are currently lacking

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