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The core functions of astrocytes include controlling the homeostasis of neurotransmitters (through uptake, catabolism and the supply of precursors), K + buffering, metabolic support, scavenging of reactive oxygen species (ROS), regulation of water transport and interstitial fluid, formationthrough perivascular endfeetof the parenchymal component of the bloodbrain barrier (glia limitans perivascularis), contribution to chemosensing, regulation of energy homeostasis, participation in transmitophagy, and many other processes 14

Thus, primed hPSCs rely on glycolysis and glutaminolysis, in which glutamine is subsequently catalyzed to -KG, replenishing the TCA cycle 48 (Fig

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease