gamma-glutamyl transpeptidase in glutathione biosynthesis Frontiers Glutathione Synthase - an overview

Rutter M, Saunders B, Wilkinson K, Rumbles S, Schofield G, Kamm M, et al

This is a considerable oversimplification because there are diverse mechanisms of brain inflammation 49

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FINO2 Initiates Ferroptosis through GPX4 Inactivation and Iron Oxidation

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So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets