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In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)

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10.1023/A:1005814109732 Summary Keywords reactive oxygen species, abiotic stress, redox homeostasis, ascorbate-glutathione pathway, isoforms, gene families Citation Pandey P, Singh J, Achary VMM and Reddy MK (2015) Redox homeostasis via gene families of ascorbate-glutathione pathway

For example, autophagy is inhibited by the cIII inhibitors Antimycin A or myxothiazol (Vogel et al., 2007), found as a parkin substrate and co-localized with LC3B in CCCP-treated macrophages ( via a similar mechanism in the nervous system