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In line with this, a study has shown that temozolomide efficacy in mice-bearing tumour cells was associated with microbial composition in the gut [192]

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25-OHC treatment significantly inhibited sterol regulatory element-binding protein (SREBP) expression in IMS32 Xuewang cells, downregulated GXP4 and stearoyl-CoA desaturase 1 (SCD1), and upregulated PTGS2, thereby increasing intracellular ROS levels and promoting ferroptosis

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