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As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate

Optical densities of bands in each blot were quantified using Image J Software and normalized with their respective control

2020 , 2 , e12222

However, determining the most effective creatine supplementation protocol has proven challenging

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Daily treatment with GW9662 did not alter the absolute numbers of day-8 FL-DCs ( Figure 5A , right ) or the cDC subset ( Figure 5E