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In a mouse model study, psychological stress-induced oxidative damage disrupted the granulocyte-lymphocyte balance, increasing granulocyte count, elevating ROS production, and raising peroxynitrite levels and lipid peroxidation in the brain, heart, liver, and spleen [223]

doi: 10.1016/j.xfre.2022.12.003 132 DabravolskiSANikiforovNGEidAHNedosugovaLVStarodubovaAVPopkovaTVet al

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The third mechanism is systemic anti-inflammatory signaling, which reduces the inflammatory load that would otherwise slow the structural remodeling process in tendons, ligaments, and muscle