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Shurin and Umansky reviewed data showing HIF-1 inhibition boosted the complete response rate to anti-PD-1 from ~25% to ~67% in murine tumors by decreasing immunosuppressive TAMs and MDSCs while increasing CTLs and NK cells (224)

SERPINB2, an early responsive gene to epigallocatechin gallate, inhibits migration and promotes apoptosis in esophageal cancer cells

Rho GTPases are members of the Ras superfamily and act as molecular switches to control multiple cell processes, such as migration, phagocytosis, cell cycle progression, and apoptosis via activation of multiple kinase pathways

The pathophysiology of benign prostatic hyperplasia.Drugs Today2002

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Ruemmele FM, Beaulieu JF, Dionne S et al (2002) Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha