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Moreover, ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1 (CHaC1) also regulates GSH degradation and has been detected to be downregulated in some tumor cells (Hong et al., 2021

Nat Catal 6 , 927938 (2023)

10.1016/j.envexpbot.2011.07.002 7 AnjumN

Novel multi-antioxidant approach for ischemic stroke therapy targeting the role of oxidative stress

Supplementation with GSH rescues cancer cell survival and growth in cystine-deficient conditions, and this rescue depends on the catabolic activity of -glutamyltransferases

Figure 2 4.1 Oxidative stress and vascular smooth muscle cells The onset of AD is typically concurrent with the deterioration of contractility in VSMCs and the buildup of inflammatory mediators