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Therefore, inhibiting GLS could effectively starve cancer cells of the glutamine essential to their survival and prevent further glutathione synthesis, thus increasing cancer cell exposure to excessive ROS levels [40]

Health conditions linked to oxidative stress include Diabetes Cancer Alzheimers disease Parkinsons disease Male infertility Cardiovascular conditions like stroke, heart disease, atherosclerosis, and high blood pressure Inflammatory disorders like arthritis 2

Clinical Cancer Research, 19 (3), 560570

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