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It seems that the regeneration program initiated after the toxic insult via cuprizone proceeds in a highly controlled manner running sequences of tightly orchestrated events on molecular and cellular levels beginning with an activation of microglia and astrocytes as a response to the oligodendrocyte insult within the first 3 weeks of cuprizone feeding followed by a massive proliferation of all glial cells and myelin clearance between the third and fifth week, and onset of remyelination around week 5.5 (Figures 3, 4)

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This helps maintain a balance between repair and regeneration, ultimately preventing the progression of fibrosis in IPF