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This endogenous antioxidant system includes small-molecular-weight antioxidants [vitamin E, melatonin, glutathione (GSH), uric acid, etc], classic antioxidant enzymes [superoxide dismutases (SODs), catalase, and glutathione peroxidase (GPx)], other antioxidant enzymes [peroxiredoxins (PRXs), thioredoxins (TRXs)], phase II detoxifying enzymes [glutathione-S-transferase (GST) isozymes, NADP(H), quinone oxidoreductase (NQO1), etc], stress-response proteins [heme oxygenase (HO)-1, ferritin, etc.], mucins (MUC), and metal binding proteins (lactoferrin, transferrin, metallothionein, etc) (Walters et al., 2008)

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