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Keywords included the following: ferroptosis, iron death, atherosclerosis, depression, cardiovascular and cerebrovascular disease, major depressive disorder, and Traditional Chinese medicine. Searches were conducted using multiple online databases, including Google Scholar, PubMed, Scopus, Embase, Web of Science, and ScienceDirect, for English-language journal reports and articles published up to October 2024

52 ChoiI.WooJ

The inactivation of Dnmt3a and Dnmt3b during early embryonic development hindered de novo methylation (Feng et al., 2010)

New drug delivery systems for Chinese herbal medicines can also exert synergistic effects via dual mechanisms to alleviate RF

However, temporal associations in this case were complicated by several factors

A significant characteristic of LA is that it can be absorbed into both intra- and extracellular fluid, while being able to form complexes with metals previously bound to other sulfhydryl proteins, thus giving an advantage to LA as a metal chelator (Flora, 2009)