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26 , 27 , 29 , 30 , 31 , 247 , 248 Epidemiological investigations have shown that patients with gastrointestinal diseases may be at increased risk of ALS 247 and antibiotic use may affect the incidence of ALS by altering the intestinal microecology

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Mizoguchi et al .[] and Papanikolaou et al .[] observed that Salmonella typhimurium and Salmonella dublin -induced colitis on mice shows inflammation similar to histopathological characteristics to human UC, including epithelial crypt loss, erosion, and neutrophil inflltration

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