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127 , 128 These reactions are considered intermediate steps in DNA demethylation, but interestingly, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine also exhibit replication dependent dilution and each has specific reader proteins, 129 131 suggesting that these modifications may be functional during development

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A systematic review and meta-analysis conducted by In summary, some controversies remain regarding the effects of SSRIs on embryonic development, and heterogeneity may exist owing to the different definitions of congenital malformations used in different studies, especially those related to CHD (Figure 2)