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To systematically evaluate the therapeutic advantages of the dual-protein targeting strategy of Psa-AR through simultaneous degradation of AR and HSP90 in overcoming tumor drug resistance, this study compared the antitumor efficacy of Psa-AR with that of current clinical regimens (including the AR inhibitor enzalutamide, the HSP90 inhibitor pimitespib, and their combination) in 22Rv1 xenograft models (Fig

In vivo estimates of liver metabolic flux assessed by 13C-propionate and 13C-lactate are impacted by tracer recycling and equilibrium assumptions

The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth)

Testosterone might cause relaxation of human corpus cavernosum by potassium channel opening action

PMID: 155 GiangSLa CavaA