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The retrospective nature of the study and absence of randomization increase the risk of selection and measurement bias, p

Cells become more responsive to proliferative signals, accelerating the rebuilding process in damaged tissue

Despite the borderline significance observed between the groups during the 9-year period, it is important to interpret the results cautiously due to the lack of significant difference in the multivariable-adjusted Cox regression analysis

Microscopically, transmural hyperemia of the gastrointestinal tract, intestinal mucosa villi reduction, crypt reduction with focal denudation of superficial epithelia, and large bowel dilatation were all inhibited

Thus, targeting the tumor vasculature can be a potential solution to enhance anti-cancer immunity and overcome resistance to ICIs

It has been the subject of hundreds of published preclinical studies examining its effects across multiple tissue types