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We note that, in accordance with section 16002 of the 21st Century Cures Act, we apply a budget neutrality factor calculated as if the cancer hospital adjustment target payment-to-cost ratio was 0.88, not the 0.87 target payment-to-cost ratio we discuss in section II.F

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For progressive forms, such as secondary progressive MS (SPMS) and primary progressive MS (PPMS), therapeutic options are limited compared to relapsingremitting MS (RRMS) [141]

Approximately 33% of patients had two or more tests during this time period

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